Explore our top-tier standardized active pharmaceutical and cosmetic ingredients, backed by ISO/GMP compliant testing and complete regulatory documentation.
Phytochemical Architecture of Psoralea Corylifolia Extract
As premier Chinese manufacturers and global exporters, Xi'an Le-Nutra Ingredients Inc. utilizes advanced liquid-liquid countercurrent distribution, molecular distillation, and supercritical CO2 extraction technology to isolation-grade compounds from the ripe seeds of Psoralea corylifolia L. (Leguminosae family, locally termed 补骨脂 - Bu Gu Zhi). The pharmacological activity of Psoralea corylifolia extract is predominantly dictated by two distinct, highly potent active molecular groups: Meroterpenes (principally Bakuchiol) and Furocoumarins (Psoralen and Isopsoralen), alongside a dense spectrum of Prenylflavonoids (Corylifol A, Neobavaisoflavone, and Bavachin).
Key Chemical Identifiers & Marker Compounds
Our extraction facilities produce standardized fractions tailored specifically for distinct industrial intents. Whether your target application is a non-irritating phytotherapeutic retinol replacement for dermatological cosmetics, or high-potency photochemotherapeutic substrate materials for specialized pharmacology, our analytical purity meets stringent USP/EP standards.
| Active Chemical Compound | Molecular Formula & CAS | Assay Standard (HPLC) | Primary Physiological Target | Industrial Applications |
|---|---|---|---|---|
| Bakuchiol | C18H24O | 10309-37-2 | 90%, 95%, 98% Clear Liquid | Retinoic Acid Receptor (RAR) Gene Expression, Collagen I/III/IV upregulation | Anti-aging cosmeceuticals, acne therapies, sensitive skin serums |
| Psoralen | C11H6O3 | 66-97-7 | 10% - 98% Fine Powder | DNA Intercalation & UVA Photobinding (PUVA therapy mechanism) | Dermatological APIs, Vitiligo & Psoriasis treatments |
| Isopsoralen (Angelicin) | C11H6O3 | 523-50-2 | 10% - 98% Crystalline Powder | Osteoblast Differentiation via Wnt/β-Catenin Signaling Pathway | Bone health supplements, postmenopausal hormone balancing |
| Corylifol A & Bavachin | C20H20O4 | 63080-31-1 | 5% - 20% Flavonoid Complex | SIRT1 Activation & Bacterial Efflux Pump Inhibition | Broad-spectrum microbial preservation, metabolic anti-inflammatory blends |
Our state-of-the-art 60,000 m² automated production complex in Shaanxi operates at the nexus of traditional botanical wisdom and Industry 4.0 process engineering.
Precision Fractionation & Molecular Distillation
Traditional solvent extraction leaves behind cytotoxic concentrations of furocoumarins that induce phototoxicity. Our factory employs a proprietary multi-stage molecular distillation unit operating under deep vacuum (<0.01 mbar). This selectively isolates Bakuchiol from phototoxic Psoralen/Isopsoralen isomers, yielding cosmetic-grade Bakuchiol (>98%) that is fully photo-safe for daytime application.
Fully Traceable Raw Material Sourcing (GAP Bases)
Supply chain resilience begins at the agricultural source. We maintain exclusive Good Agricultural Practices (GAP) contract farming agreements across prime micro-climates in Sichuan and Henan provinces. Every batch of Psoralea corylifolia seed undergoes strict pre-harvest testing for heavy metals (Pb, Cd, As, Hg), organochlorine pesticides, and aflatoxins B1/B2/G1/G2 before intake.
High-Throughput Continuous Extraction Lines
Equipped with six multifunctional extraction tanks integrated with automated PLC system monitoring, our facility processes over 3,000 metric tons of botanical raw material annually. Intelligent temperature and pressure feedback loops eliminate batch-to-batch variance, maintaining a thermal profile that protects delicate natural terpenes against oxidative degradation.
We engineer customized Psoralea Corylifolia raw material specifications aligned with precise international regulatory and product development matrices.
Phyto-Retinol Cosmeceutical Formulations
In clean beauty and dermatological anti-aging formulations, synthetic retinol faces significant consumer resistance due to erythema, peeling, and photo-instability. Our Pure Bakuchiol 98% acts as a functional retinoid analog. It stimulates Gene Expression Profiles similar to retinol (upregulating CRABP2 and TIG1) without inducing cutaneous inflammation or photo-sensitization.
- Excellent oil-solubility for serums and emulsions
- Stable in sunlight; permits daytime application
- Clinical performance: Reduction in wrinkle depth & hyperpigmentation
Dermatological APIs & PUVA Phototherapy
For global pharmaceutical laboratories synthesizing vitiligo, alopecia areata, and severe psoriasis treatments, our high-purity Psoralen (98% HPLC) serves as a reliable photosensitizing active pharmaceutical ingredient (API). When coupled with controlled long-wave ultraviolet light (UVA), it induces DNA cross-linking in hyperproliferative epidermal cells to restore normal epidermal kinetics.
- Complies with USP/EP monograph criteria
- Ultra-low residual organic solvent limits (ICH Q3C compliant)
- Custom particle size micronization available
Orthopedic & Menopausal Health Formulations
Psoralea corylifolia prenylflavonoids demonstrate marked phytoestrogenic activity. Our standardized Isopsoralen & Bavachin extracts are designed for dietary supplement manufacturers targeting bone mineral density loss, osteoclast inhibition, and postmenopausal wellness support through estrogen receptor-beta (ER-β) selective modulation.
- Standardized flavonoid profiles for dose consistency
- Non-GMO water-soluble and ethanol-extracted grades
- Heavy metal-tested for daily nutritional safety
We streamline international supply chains by bridging technical quality assurance with comprehensive regulatory compliance.
Complete Regulatory Dossiers
Global qualification requires immediate access to documentation. Every shipment of our Psoralea Corylifolia extract is supplied with batch-specific Certificates of Analysis (COA), Safety Data Sheets (SDS/MSDS compliant with GHS), Allergen Declarations, Non-GMO verification, and REACH pre-registration data for EU distribution.
Microbiological & Chemical Purity
Operating under ISO9001:2015 and cGMP guidelines, our in-house quality assurance center runs HPLC-DAD, GC-MS, and ICP-MS testing. We strictly guarantee zero presence of adulterants (such as added synthetic retinol or synthetic terpenes), compliant total plate counts (<1000 CFU/g), and absence of E. coli and Salmonella.
Flexible OEM/ODM Customization
Recognizing that client formulations vary, we offer tailored viscosity adjustments, carrier solubilization (e.g., pre-dissolved Bakuchiol in Caprylic/Capric Triglyceride), custom mesh sizes for solid powder extracts, and private label nitrogen-purged drum packaging to prevent oxidation during sea/air transit.
As a forward-thinking ingredient supplier, Xi'an Le-Nutra Ingredients Inc. is investing in next-generation bio-engineering technologies to ensure long-term botanical sustainability and enhanced bio-efficiency.
1. Liposomal & Nano-Encapsulation Delivery
To increase skin penetration speed and stability in aqueous cosmetic matrices, our R&D pipeline features nano-liposomal Bakuchiol complexes. By encapsulating high-purity Bakuchiol within phospholipid bilayers, formulators can achieve crystal-clear water solubility without phase separation.
2. Green Decarbonized Solvent Systems
Aligning with global ESG and carbon-neutral initiatives, our factory is transitioning traditional extraction lines to natural deep eutectic solvents (NaDES) and supercritical fluid technology, reducing energy footprint by 35% while eliminating volatile organic compound (VOC) emissions.
3. Synthetic Biology & Enzymatic Biotransformation
In partnership with top-tier Chinese biotechnology universities, we are exploring yeast-based biosynthesis pathways for isolated meroterpenes, offering a dual-track strategy combining wild-crop sustainability with high-yield bio-identical fermentation.
Our global logistics network guarantees swift cross-border delivery, rapid sample clearance, and full compliance across major international markets.
North America
FDA Facility Registered, US warehouse staging for emergency stock delivery within 48 hours.
European Union
REACH compliant, low furocoumarin cosmetic grades tailored to EC 1223/2009 standards.
Asia-Pacific
Full INCI registration for China, Japan (Quasi-Drug standards), and South Korea (KFDA compliant).
Latin America / MEA
Halal & Kosher certified facilities with comprehensive customs documentation support.
Clear answers to crucial engineering, regulatory, and sourcing questions regarding Psoralea Corylifolia extracts.
We employ a proprietary liquid-chromatographic separation process combined with high-vacuum molecular distillation. This allows us to separate Bakuchiol (a meroterpene) from the furocoumarin fractions (Psoralen & Isopsoralen) based on differential boiling points and molecular weights. Our cosmetic-grade Bakuchiol 98% contains less than 50 ppm (<0.005%) total furocoumarins, making it completely non-phototoxic and suitable for daytime use.
The clinically validated usage concentration for pure Bakuchiol is between 0.5% and 1.0% w/w. Bakuchiol is highly lipophilic (oil-soluble). It should be incorporated into the oil phase or added during the cool-down phase (<50°C) of emulsion manufacturing to preserve its antioxidant integrity. It dissolves readily in carrier oils, esters, and Caprylic/Capric Triglycerides.
Unlike Retinol, which rapidly degrades under UV light and generates reactive oxygen species, Bakuchiol is exceptionally photo-stable and acts as a powerful lipid antioxidant. In stability testing, Bakuchiol retains over 95% potency after 48 hours of continuous UV exposure, whereas Retinol degrades by over 80% under identical conditions.
We provide complete technical dossiers including Batch COA, Safety Data Sheet (SDS), Technical Data Sheet (TDS), Method of Analysis (HPLC conditions), Heavy Metal & Pesticide Residue Reports, Non-GMO Statement, TSE/BSE Free Certificate, and IFRA compliance statements. EU REACH pre-registration data is also available upon request.
Standard MOQs for standardized bulk extracts start at 1 kg for high-purity actives (e.g., Bakuchiol 98%) and 25 kg (standard fiber drum) for powder extracts. Samples (10–50g) are dispatched via DHL/FedEx within 24 to 48 hours. Commercial orders ship within 5–7 business days from our Xi’an central warehouse.
Discover our extended line of nutraceutical, cosmetic, and functional peptide active raw materials engineered to international standards.
