Primary Bio-Actives & Engineered Extract Series
Explore our verified functional raw materials and active pharmaceutical/nutraceutical precursors, manufactured under clean-science protocols with batch-tested certificates.
The Convergence of Phosphocreatine Resynthesis & Extracellular Matrix Regeneration
In modern clinical nutrition and sports science, the simultaneous administration of micronized creatine monohydrate and enzymatically hydrolyzed collagen peptides represents one of the most commercially robust and biochemically validated formulations. While creatine works primarily at the cellular energetic level within the adenosine triphosphate-phosphocreatine (ATP-PCr) system, hydrolyzed collagen peptides deliver structural signaling molecules—specifically bioactive prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly)—that trigger human fibroblasts and osteoblasts via integrin receptor phosphorylation.
As an enterprise-level ODM Creatine and Collagen Peptides supplier and manufacturer, Xi'an Le-Nutra Ingredients Inc. bridges the gap between pharmaceutical molecular purity and industrial scalability. With 14+ years of specialized ingredient manufacturing, our multi-tank enzymatic cleavage lines solve historical industry pain points: poor solubility, organoleptic bitterness, heavy metal cross-contamination, and rapid sedimentation in functional beverage systems.
By coordinating our supply with world leaders such as BASF, DSM, 3SBio, Abbott, and Estée Lauder, we enforce stringent analytical controls across HPLC purity profiles, chiral purity verification, and mass spectrometry peptide distribution analysis.
| Technical Parameter | Creatine Monohydrate (ODM) | Hydrolyzed Collagen Peptides |
|---|---|---|
| Chemical Identity | N-Amidinosarcosine (CAS 57-00-1) | Enzymatic Hydrolysate (CAS 9064-67-9) |
| Molecular Weight | 149.15 g/mol (Monohydrate) | Customized: 800 – 3,000 Daltons |
| Assay / Protein | ≥ 99.5% (Titration/HPLC) | ≥ 90.0% Pure Peptide Protein |
| Dicyandiamide / Impurities | ≤ 20 ppm (Ultra-Pure Grade) | Undetectable / Strict Ash < 2% |
| Physical Granulation | 80 Mesh / 200 Mesh Micronized | Agglomerated Instantized Granules |
| Cold Water Solubility | Complete dispersion without cakes | 100% Instant Clear Solution |
Targeted Application Formulations for B2B Brand Scalability
From clean-label athletic powders to medical-grade functional nutrition, our contract customization addresses exact regional consumer preferences and regulatory compliance profiles.
1. Elite Sports Performance & Explosive Power
Formulated for high-intensity training, combining 200-mesh micronized creatine monohydrate with high-proline bovine/marine collagen peptides. This dual-matrix accelerates high-load cross-sectional muscle myofibrillar hypertrophy while reinforcing connective tendinous sheaths, preventing common strain injuries in strength athletes.
2. Sarcopenia Interventions & Healthy Aging
Designed for the rapidly expanding geriatric wellness market across Europe, Japan, and North America. Low-molecular-weight collagen peptides (<1,500 Da) coupled with gentle, non-bloating creatine micro-dosing directly counteract age-related denervation, muscle wasting, bone mineral density decline, and joint capsule stiffness.
3. Ingestible Beauty & Nutricosmetics
Engineered exclusively with deodorized, marine-derived fish collagen peptides standardized to glycine-proline-hydroxyproline tripeptides. Creatine serves as an intracellular bioenergetic engine for dermal keratinocytes, optimizing cellular hydration turnover, increasing collagen cross-linking density, and diminishing photo-aging markers.
4. Orthopedic & Clinical Joint Recovery
Targeting post-operative orthopedic recovery and rheumatoid wellness. Our bio-enzymatic Type II undenatured collagen works synergistically with creatine monohydrate to dampen pro-inflammatory NF-κB signaling pathways, promoting articular cartilage repair while maintaining joint lubrication under repetitive axial strain.
5. Ready-to-Drink (RTD) Beverages & Liquid Shots
Solving creatine's notorious degradation into inactive creatinine in acidic aqueous environments. Utilizing our proprietary liposomal microencapsulation and buffering stabilization technologies, we provide RTD brand owners with ready-to-fill premixes boasting 18-month shelf-stability at ambient temperatures.
6. Hybrid Functional Food Confectioneries & Gummies
Overcoming heat denaturation and gelling conflicts during high-temperature candy depositing. We engineer heat-stable peptide hydrolysates and non-hygroscopic creatine crystals specifically calibrated for pectin and gelatin gummie matrices with zero crystalline bloom or grittiness.
Next-Generation Molecular Engineering & Extraction Roadmap
Our technology roadmap outlines continuous investments into enzyme catalysis, selective peptide cut sites, and green synthesis to elevate bio-absorption and physical processing stability.
Site-Specific Endopeptidase Cleavage
Departing from non-selective acid/alkali degradation. We implement multi-enzyme combinatorial cleavage using targeted endoproteases and exopeptidases. This retains essential Gly-Pro-Hyp bioactive sequences while eliminating bitter hydrophobic amino acid terminal sequences.
Ceramic Nano-Membrane Dialysis
Employing progressive multi-stage ceramic ultrafiltration cascades with automated molecular weight cutoffs (MWCO). We isolate targeted molecular fractions (e.g., 1,000–2,000 Da) while stripping residual inorganic salts, free heavy metals, and organoleptic volatiles.
Fluidized Bed Agglomeration & Micronization
Optimizing powder flowability and bulk density through co-spray drying and secondary fluidized bed granulators. Raw crystalline creatine is micronized via supersonic air-jet milling to 200 mesh (D90 < 75 μm) for instant hydration without mechanical shear.
Smart Liposomal & Enteric Microencapsulation
Addressing gastrointestinal breakdown and renal elimination. Advanced lipid bilayer nano-encapsulation shields active peptides and creatine from low gastric pH, ensuring targeted intestinal epithelial absorption via PEPT1 active peptide transporters.
China Factory Supply Chain Resilience: The Xi'an Le-Nutra Advantage
In the global functional ingredient market, raw material price volatility, energy disruption, and geopolitical supply constraints threaten brand continuity. Xi'an Le-Nutra Ingredients Inc. operates from an optimized bio-industrial ecosystem in Shaanxi, China, leveraging comprehensive vertical integration from upstream chemical raw materials (sarcosine, cyanamide) and food-grade collagen substrates (traceable bovine, porcine, and deep-sea wild-caught cod skins) to final spray-dried powders.
Our 60,000 square meter intelligent manufacturing facility hosts 6 automated multifunctional production lines. Equipped with continuous countercurrent extraction batteries, vacuum low-temperature falling film evaporators, and 3,000-ton annualized capacity spray dryers, we minimize thermal stress on bio-active peptide chains while drastically reducing per-kilogram thermal energy expenditures.
- Continuous Raw Material Reserve: Buffer inventories of certified precursors guarantee price stability and uninterrupted contract supply across 6 to 12-month delivery contracts.
- Scale Economy & Cost Efficiency: Our fully automated closed-loop systems reduce manufacturing overhead by up to 28% compared to Western European toll-processors, passing margin value to private-label brands.
- Logistics Network Integration: Located at the central hub of China's Belt and Road Initiative and high-speed freight arteries, connecting directly to Qingdao, Shanghai, and Tianjin maritime ports with temperature-controlled containerization.
Quality & Supply Chain KPIs
Global Regulatory Assurance & Local Market Entry
Streamlining the path to global market approvals through exhaustive technical documentation, multi-jurisdiction compliance dossiers, and third-party credentialing.
North America (FDA 21 CFR & GRAS)
Full documentation for FDA GRAS (Generally Recognized as Safe) notifications, NDI (New Dietary Ingredient) assessments, strict compliance with FDA 21 CFR Part 111 cGMP dietary supplement rules, and complete third-party laboratory panel testing for California Proposition 65 compliance.
European Union (EFSA & Novel Foods)
Thorough technical dossiers matching EFSA dietary guidelines. Batch-verified non-BSE/TSE veterinary certificates for animal collagen origins, non-GMO declarations, zero allergen cross-contact assurances, and REACH chemical registration compliance for technical derivatives.
Middle East, APAC & Latin America
MUI Halal and Star-K Kosher certified facilities, meeting all religious dietary laws. Support for Health Canada NPN applications, ASEAN cosmetic/supplement harmonized dossiers, China SAMR "Blue Hat" filings, and LATAM ANVISA registrations with fully authenticated Certificate of Free Sale (CFS).
Frequently Asked Questions for Sourcing & Formulation Leaders
Get precise engineering, manufacturing, and regulatory answers regarding our custom ODM Creatine and Collagen Peptides manufacturing operations.
How does Le-Nutra eliminate toxic manufacturing by-products (DCD and DHT) in creatine production?
What is the optimal molecular weight distribution for collagen peptides in ODM formulations?
• Dermal Elasticity & Anti-Aging: High fraction of di- and tri-peptides (Pro-Hyp, Hyp-Gly) calibrated between 800 and 1,500 Da for immediate paracellular absorption.
• Joint & Cartilage Regeneration: Targeted 2,000 to 3,000 Da fragments optimized for chondrocyte receptor stimulation.
• Sports Nutrition & Satiety: 3,000 to 5,000 Da fractions offering functional bulk, instant dispersibility, and superior organoleptic profiles.
Can creatine monohydrate and collagen peptides be co-formulated in ready-to-drink (RTD) beverages?
What documentation and technical dossiers accompany each export shipment?
• Batch-specific Certificate of Analysis (COA) specifying assay, moisture, heavy metals (Pb, As, Cd, Hg via ICP-MS), mesh size, bulk density, and total microbiological counts.
• Globally harmonized Safety Data Sheet (SDS/MSDS) in English.
• Technical Specification Sheet (TDS) and Allergen-Free Statement.
• BSE/TSE-Free Declarations for animal-origin materials and Non-GMO certifications.
• HPLC chromatograms and molecular mass distribution curve charts upon formulation qualification request.
What is the typical Minimum Order Quantity (MOQ) and production turnaround for custom ODM projects?
Specialized Plant Proteins & Active Cosmeceutical Precursors
Expand your brand portfolio with our enzymatically hydrolyzed plant peptides, high-purity tyrosinase inhibitors, and certified hypoallergenic vegetal isolates.
